Senior Analytical Scientist – Mass Spectrometry - Antibody Drug Conjugates Location: London, UK (Hybrid) Are you ready to revolutionize oncology treatments? Join an innovative biotech company at the forefront of developing proprietary Antibody-Drug Conjugates (ADCs) that are redefining cancer care. With a strong pipeline of clinical and preclinical programs, this company is blending expertise in antibody engineering, bioconjugation, and analytical sciences to deliver life-changing therapies. Their state-of-the-art labs are the epicenter of groundbreaking R&D, and they’re seeking a talented Senior Analytical Scientist to drive the development of next-generation ADCs, using cutting-edge analytical techniques and mass spectrometry. Your Role: Lead the development of robust antibody characterization workflows, including stress testing, sequence liability analysis, and PTM/glycan profiling. Collaborate with Bioconjugation and Downstream Manufacturing teams to optimize analytical protocols, including drug-to-antibody ratio (DAR) determinations. Partner with Antibody Engineering to innovate and characterize novel antibody and ADC formats. Keep meticulous records of experiments and foster seamless communication across interdisciplinary teams. Play a pivotal role in a cross-functional project team, advancing preclinical ADC assets through the early stages of drug discovery. Your Expertise: Qualifications: BSc/MSc in Life Sciences or Chemistry with a strong foundation in Biochemistry. Analytical Skills: Mastery of mass spectrometry techniques (e.g., peptide mapping, DAR determination), proficiency with tools like MassHunter and Agilent systems. Technical Proficiency: Expertise in LC-MS, HIC-HPLC, SEC, IEX, and RP-HPLC; experience with Chromeleon and Vanquish UHPLC systems is a bonus. Track Record: Demonstrated ability to develop and troubleshoot analytical methods for protein and conjugate characterization. Collaboration: Excellent interpersonal and communication skills, thriving in multidisciplinary environments. Industry Savvy: Experience in biotech or industry settings. Bonus Points For: HPLC expertise in protein quantitation, charge variant analysis, and glycan profiling. Small molecule mass spectrometry, including payload cleavage studies. Hands-on experience with AKTA purification systems and Unicorn software. Familiarity with biomolecule tracking software like Genedata Biologics. What’s In It for You? This role comes with a competitive benefits package, including: Annual travel allowance and performance-based bonus. 30 days of holiday plus bank holidays, with an additional Christmas shutdown. Matched pension contributions, private health insurance, share options, and social incentives. Why Join? Be part of a dynamic, forward-thinking team that values scientific innovation and collaboration. This is your chance to work on transformative oncology therapies, expand your expertise, and contribute to a mission that truly makes a difference. Take the next step in your career—apply now and help shape the future of cancer treatment