Research Assistant Job Type: Full-Time. Starting Salary: £43003 - £46297 per annum 43003 plus benefits To find out more about the job please click the ‘apply for job’ button to be taken to Imperial job site About the role We are seeking a neuropathology Research Assistant to work on an innovative, large-scale, public-private partnership that will use multiple layers of genomic and state-of-the-art neuropathology data generated on human post-mortem brain tissue for drug target identification and prioritisation. What you would be doing The Landmark Project is a public-private partnership funded by Parkinson's UK in collaboration with a consortium of global Pharma companies. The post offers opportunities to work on an internationally unique, large-scale dataset using cutting edge methods for causal inference and multiomic data integration, as well as opportunities to interact with leading drug development scientists globally. What we are looking for Candidates must hold a good first degree or equivalent - e.g. BSc / BA in biological sciences or other appropriate discipline, or equivalent vocational qualification and / or equivalent experience in laboratory management Experience in handling human tissues (fresh, frozen, fixed), preferably tissues of the central nervous system (CNS) Experience of sectioning of paraffin embedded tissue blocks, preferably human CNS, and tinctorial and immunohistochemical staining of paraffin sections Experience of cryosectioning and tinctorial and immunohistochemical staining of frozen sections Knowledge of neuroanatomy Knowledge of neuropathology The ability to manage a research project including planning of experimental milestones Excellent communication skills and the ability to deal with a wide range of people and manage small teams Ability to write clearly and succinctly for publication Ability to work productively including motivate others to produce a high standard of work Ability to organise own work with minimal supervision Ability to prioritise own work in response to deadlines What we can offer you The post offers opportunities to work on an internationally unique, large-scale dataset using cutting edge methods for causal inference and multiomic data integration. Opportunities to interact with leading drug development scientists globally A key focus of the research is drug target discovery for Parkinson's disease (PD), but the research will support target and biomarker discovery across human brain disease broadly. A unique feature of the project is that each brain tissue sample will be linked to quantitative neuropathology, including measures of oligomeric tau and alpha-synuclein levels. We anticipate the generation of scRNA-seq profiles on up to 30 million cells across 1,000 samples, providing a globally important resource for drug target discovery. The RA will work in a multidisciplinary team consisting of neuropathologists, neurologists, bench scientists, computational biologists and statisticians. The Landmark Project will have an international profile The opportunity to continue your career at a world-leading institution and be part of our mission to continue science for humanity. Grow your career: Gain access to Imperial's sector-leading dedicated career support for researchers as well as opportunities for promotion and progression Sector-leading salary and remuneration package (including 39 days off a year and generous pension schemes). Further information This is a 2 year Fixed Term contract based at our Hammersmith Campus. If you require any further details on the role, please contact: Mike Johnson - m.johnsonimperial.ac.uk